MGP Database

MGP003232

Record overview

MGPD ID	MGP003232
Gene ID	7306
Species	Homo sapiens (Human)
Gene Name	tyrosinase-related protein 1
Gene Symbol	TYRP1
Synonyms	TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN;
Alternate names	5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75;
Chromosome	9
Map Location	9p23
EC Number	1.14.18.-
Summary	This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
Orthologs	View orthologs and multiple alignments for TYRP1

Proteins

5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

Refseq ID:	NP_000541
Protein GI:	4507757
UniProt ID:	P17643
mRNA ID:	NM_000550
Length:	537
RefSeq Status:

MSAPKLLSLGCIFFPLLLFQQARAQFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCH
CNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTF
LGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLG
TLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIF
VLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPSREFSVPEIIAIAVVGALLLVALIFGTASYL
IRARRSMDEANQPLLTDQYQCYAEEYEKLQNPNQSVV

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2665
peptide sequence: 
MSAPKLLSLGCIFFPLLLFQQARA

mat_peptide: 25..537
product: 5,6-dihydroxyindole-2-carboxylic acid oxidase
calculated_mol_wt: 58077
peptide sequence: 
QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQ
RVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWH
RYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMV
QRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADIST
FPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPSREFSVPEIIAIAVVGALLLVALIFGTASYLIRARRSMDEANQPLLTDQYQCYAE
EYEKLQNPNQSVV