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MGP003239

Record overview

MGPD IDMGP003239
Gene ID7319
SpeciesHomo sapiens (Human)
Gene Nameubiquitin-conjugating enzyme E2A
Gene Symbol UBE2A
SynonymsUBC2; HHR6A; MRXSN; RAD6A; MRXS30;
Alternate namesubiquitin-conjugating enzyme E2 A; RAD6 homolog A; ubiquitin carrier protein A; ubiquitin-protein ligase A;
ChromosomeX
Map LocationXq24
EC Number6.3.2.19
SummaryThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for UBE2A

Proteins

ubiquitin-conjugating enzyme E2 A isoform 1
Refseq ID:NP_003327
Protein GI:32967280
UniProt ID:P49459
mRNA ID:NM_003336
Length:152
RefSeq Status:
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTY
DVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC
 
ubiquitin-conjugating enzyme E2 A isoform 2
Refseq ID:NP_861427
Protein GI:32967276
UniProt ID:P49459
mRNA ID:NM_181762
Length:122
RefSeq Status:
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLY
QENKREYEKRVSAIVEQSWRDC
 
ubiquitin-conjugating enzyme E2 A isoform 4
Refseq ID:NP_001269090
Protein GI:531990811
UniProt ID:P49459
mRNA ID:NM_001282161
Length:119
RefSeq Status:
MVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQEN
KREYEKRVSAIVEQSWRDC
 
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