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MGP003247

Record overview

MGPD IDMGP003247
Gene ID7327
SpeciesHomo sapiens (Human)
Gene Nameubiquitin-conjugating enzyme E2G 2
Gene Symbol UBE2G2
SynonymsUBC7;
Alternate namesubiquitin-conjugating enzyme E2 G2; ubiquitin carrier protein G2; ubiquitin conjugating enzyme 7; ubiquitin conjugating enzyme G2; ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-protein ligase G2;
Chromosome21
Map Location21q22.3
EC Number6.3.2.19
SummaryThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
OrthologsView orthologs and multiple alignments for UBE2G2

Proteins

ubiquitin-conjugating enzyme E2 G2 isoform 1
Refseq ID:NP_003334
Protein GI:29893557
UniProt ID:P60604
mRNA ID:NM_003343
Length:165
RefSeq Status:
MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDP
MGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
 
ubiquitin-conjugating enzyme E2 G2 isoform 2
Refseq ID:NP_872630
Protein GI:33359701
UniProt ID:P60604
mRNA ID:NM_182688
Length:137
RefSeq Status:
MNEENFFEWEALIMGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKILLSVVSMLA
EPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
 
ubiquitin-conjugating enzyme E2 G2 isoform 3
Refseq ID:NP_001189418
Protein GI:321117279
UniProt ID:P60604
mRNA ID:NM_001202489
Length:95
RefSeq Status:
MRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
 
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