MGP Database

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MGP003263

UniProt Annotations

Entry Information
Gene NameUDP-glucose pyrophosphorylase 2
Protein EntryUGPA_HUMAN
UniProt IDQ16851
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16851-1; Sequence=Displayed; Name=2; IsoId=Q16851-2; Sequence=VSP_012834;
Catalytic ActivityUTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
CautionThe human genome was initially thought to contain 2 genes for UTP--glucose-1-phosphate uridylyltransferase: UGP1 and UGP2. However, the sequence defined as UGP1 (PubMed:8354390) probably does not exist and corresponds to UGP2. {ECO:0000305|PubMed:8354390}.
FunctionPlays a central role as a glucosyl donor in cellular metabolic pathways.
InteractionP62993:GRB2; NbExp=2; IntAct=EBI-743729, EBI-401755;
SimilarityBelongs to the UDPGP type 1 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:8354390}.
SubunitHomooctamer. {ECO:0000269|PubMed:22132858}.
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