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MGP003264

UniProt Annotations

Entry Information
Gene NameUDP glucuronosyltransferase 2 family, polypeptide B4
Protein EntryUD2B4_HUMAN
UniProt IDP06133
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P06133-1; Sequence=Displayed; Name=2; IsoId=P06133-2; Sequence=VSP_056679, VSP_056680; Note=No experimental confirmation available.; Name=3; IsoId=P06133-3; Sequence=VSP_056869, VSP_056870; Note=No experimental confirmation available.;
Catalytic ActivityUDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
CautionPubMed:8333863 thought that this was a new form (UGT2B11). The name UGT2B11 has now been reused for another human enzyme. {ECO:0000305}.
FunctionUDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
SimilarityBelongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ugt2b4/";
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