MGP Database

MGP003279

Record overview

MGPD IDMGP003279
Gene ID7389
SpeciesHomo sapiens (Human)
Gene Nameuroporphyrinogen decarboxylase
Gene Symbol UROD
SynonymsPCT; UPD;
Alternate namesuroporphyrinogen decarboxylase; uroporphyrinogen III decarboxylase;
Chromosome1
Map Location1p34
EC Number4.1.1.37;
SummaryThis gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
OrthologsView orthologs and multiple alignments for UROD

Proteins

uroporphyrinogen decarboxylase
Refseq ID:NP_000365
Protein GI:71051616
UniProt ID:P06132
mRNA ID:NM_000374
Length:367
RefSeq Status:
MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTM
VPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALV
PYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVT
LQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
 
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