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MGP003288

UniProt Annotations

Entry Information
Gene Namevascular cell adhesion molecule 1
Protein EntryVCAM1_HUMAN
UniProt IDP19320
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Long, VCAM-7D; IsoId=P19320-1; Sequence=Displayed; Note=Major isoform.; Name=2; Synonyms=Short, VCAM-6D; IsoId=P19320-2; Sequence=VSP_002580; Name=3; IsoId=P19320-3; Sequence=VSP_044636; Note=No experimental confirmation available.;
DomainEither the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
FunctionImportant in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
InductionBy cytokines (e.g. IL-1, TNF-alpha).
PtmSialoglycoprotein.
SimilarityContains 7 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitBinds to ECMV-D capsid proteins and acts as a receptor for this virus. {ECO:0000250}.
Tissue SpecificityExpressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=VCAM-1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_266";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/vcam1/";
Web ResourceName=Wikipedia; Note=VCAM1 entry; URL="http://en.wikipedia.org/wiki/VCAM1";
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