MGP Database

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MGP003306

Ontology/Pathway Information

Entrez Gene ID7450
Gene Namevon Willebrand factor
Gene Symbol VWF
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0031012 IDA:UniProtKBCextracellular matrix
GO:0005576 IDA:UniProtKBCextracellular region
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031091 NAS:UniProtKBCplatelet alpha granule
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005578 IEA:UniProtKB-SubCellCproteinaceous extracellular matrix
GO:0033093 IDA:UniProtKBCWeibel-Palade body
GO:0051087 IDA:UniProtKBFchaperone binding
GO:0005518 IDA:UniProtKBFcollagen binding
GO:0001948 IDA:UniProtKBFglycoprotein binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0019865 IDA:UniProtKBFimmunoglobulin binding
GO:0005178 IPI:UniProtKBFintegrin binding
GO:0002020 IPI:UniProtKBFprotease binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0047485 IPI:UniProtKBFprotein N-terminus binding
GO:0007596 IMP:UniProtKBPblood coagulation
GO:0007597 TAS:ReactomePblood coagulation, intrinsic pathway
GO:0007155 IDA:UniProtKBPcell adhesion
GO:0031589 IDA:UniProtKBPcell-substrate adhesion
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0007599 IMP:UniProtKBPhemostasis
GO:0001889 IEA:EnsemblPliver development
GO:0001890 IEA:EnsemblPplacenta development
GO:0030168 IDA:UniProtKBPplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0051260 IDA:UniProtKBPprotein homooligomerization
GO:0009611 TAS:UniProtKBPresponse to wounding
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118779Extracellular matrix organization
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_23847GP1b-IX-V activation signalling
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_604Hemostasis
REACT_15523Integrin alphaIIb beta3 signaling
REACT_13552Integrin cell surface interactions
REACT_326Intrinsic Pathway
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_798Platelet activation, signaling and aggregation
REACT_1230Platelet Adhesion to exposed collagen
REACT_278Platelet Aggregation (Plug Formation)
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_111102Signal Transduction
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