MGP Database

MGP003319

Ontology/Pathway Information

Entrez Gene ID	7474
Gene Name	wingless-type MMTV integration site family, member 5A
Gene Symbol	WNT5A
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	IEA:Ensembl	C	cell surface
GO:0030669	TAS:Reactome	C	clathrin-coated endocytic vesicle membrane
GO:0005788	TAS:Reactome	C	endoplasmic reticulum lumen
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IDA:UniProtKB	C	extracellular space
GO:0070062	TAS:Reactome	C	extracellular vesicular exosome
GO:0005796	TAS:Reactome	C	Golgi lumen
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0005578	IEA:UniProtKB-SubCell	C	proteinaceous extracellular matrix
GO:0005109	IPI:UniProtKB	F	frizzled binding
GO:0048018	IC:BHF-UCL	F	receptor agonist activity
GO:0005115	IPI:UniProtKB	F	receptor tyrosine kinase-like orphan receptor binding
GO:0003700	IMP:UniProtKB	F	sequence-specific DNA binding transcription factor activity
GO:0044212	IDA:UniProtKB	F	transcription regulatory region DNA binding
GO:0007257	IDA:BHF-UCL	P	activation of JUN kinase activity
GO:0000187	IDA:BHF-UCL	P	activation of MAPK activity
GO:0032148	IDA:BHF-UCL	P	activation of protein kinase B activity
GO:0001667	IEA:Ensembl	P	ameboidal-type cell migration
GO:0008595	IEA:Ensembl	P	anterior/posterior axis specification, embryo
GO:0007411	ISS:UniProtKB	P	axon guidance
GO:0060070	IEA:Ensembl	P	canonical Wnt signaling pathway
GO:0051216	IEA:UniProtKB-KW	P	cartilage development
GO:0045165	IBA:GO_Central	P	cell fate commitment
GO:0034613	IDA:UniProtKB	P	cellular protein localization
GO:0071277	IEP:UniProtKB	P	cellular response to calcium ion
GO:0071346	IEP:UniProtKB	P	cellular response to interferon-gamma
GO:0071222	IEP:UniProtKB	P	cellular response to lipopolysaccharide
GO:0071300	ISS:UniProtKB	P	cellular response to retinoic acid
GO:0071560	IEP:UniProtKB	P	cellular response to transforming growth factor beta stimulus
GO:0060067	IEA:Ensembl	P	cervix development
GO:0090103	IEA:Ensembl	P	cochlea morphogenesis
GO:0060029	IEA:Ensembl	P	convergent extension involved in organogenesis
GO:0071542	IEA:Ensembl	P	dopaminergic neuron differentiation
GO:0042733	IEA:Ensembl	P	embryonic digit morphogenesis
GO:0048706	IMP:BHF-UCL	P	embryonic skeletal system development
GO:0060750	IEA:Ensembl	P	epithelial cell proliferation involved in mammary gland duct elongation
GO:0001837	IEP:UniProtKB	P	epithelial to mesenchymal transition
GO:0001736	IEA:Ensembl	P	establishment of planar polarity
GO:0060324	IMP:BHF-UCL	P	face development
GO:0048806	IMP:BHF-UCL	P	genitalia development
GO:0001947	IEA:Ensembl	P	heart looping
GO:0071425	IDA:BHF-UCL	P	hematopoietic stem cell proliferation
GO:0007442	IEA:Ensembl	P	hindgut morphogenesis
GO:0048850	IEA:Ensembl	P	hypophysis morphogenesis
GO:0030216	IEP:BHF-UCL	P	keratinocyte differentiation
GO:0060599	IEA:Ensembl	P	lateral sprouting involved in mammary gland duct morphogenesis
GO:0002088	ISS:BHF-UCL	P	lens development in camera-type eye
GO:0030324	IEA:Ensembl	P	lung development
GO:0008584	IEP:UniProtKB	P	male gonad development
GO:0060744	IEA:Ensembl	P	mammary gland branching involved in thelarche
GO:0060638	IEA:Ensembl	P	mesenchymal-epithelial cell signaling
GO:0007494	IEA:Ensembl	P	midgut development
GO:0050919	IEA:Ensembl	P	negative chemotaxis
GO:0043066	IDA:UniProtKB	P	negative regulation of apoptotic process
GO:0048843	IEA:Ensembl	P	negative regulation of axon extension involved in axon guidance
GO:0030514	IEA:Ensembl	P	negative regulation of BMP signaling pathway
GO:0090090	IDA:UniProtKB	P	negative regulation of canonical Wnt signaling pathway
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0045599	IMP:BHF-UCL	P	negative regulation of fat cell differentiation
GO:0040037	IEA:Ensembl	P	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0072201	IDA:UniProtKB	P	negative regulation of mesenchymal cell proliferation
GO:0060686	IEA:Ensembl	P	negative regulation of prostatic bud formation
GO:0051964	IEA:Ensembl	P	negative regulation of synapse assembly
GO:0045892	IDA:UniProtKB	P	negative regulation of transcription, DNA-templated
GO:0001843	IEA:Ensembl	P	neural tube closure
GO:0030182	ISS:UniProtKB	P	neuron differentiation
GO:0038031	IEA:Ensembl	P	non-canonical Wnt signaling pathway via JNK cascade
GO:0021891	ISS:UniProtKB	P	olfactory bulb interneuron development
GO:0003408	ISS:BHF-UCL	P	optic cup formation involved in camera-type eye development
GO:0060021	IMP:BHF-UCL	P	palate development
GO:0061350	IEA:Ensembl	P	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061349	IEA:Ensembl	P	planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0090179	IEA:Ensembl	P	planar cell polarity pathway involved in neural tube closure
GO:0061347	IEA:Ensembl	P	planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061354	IEA:Ensembl	P	planar cell polarity pathway involved in pericardium morphogenesis
GO:0061348	IEA:Ensembl	P	planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0045766	IMP:UniProtKB	P	positive regulation of angiogenesis
GO:0061036	IEA:Ensembl	P	positive regulation of cartilage development
GO:2000049	IEA:Ensembl	P	positive regulation of cell-cell adhesion mediated by cadherin
GO:0030825	IDA:BHF-UCL	P	positive regulation of cGMP metabolic process
GO:0045080	IMP:UniProtKB	P	positive regulation of chemokine biosynthetic process
GO:0002741	IMP:UniProtKB	P	positive regulation of cytokine secretion involved in immune response
GO:0010595	IMP:UniProtKB	P	positive regulation of endothelial cell migration
GO:0001938	IMP:UniProtKB	P	positive regulation of endothelial cell proliferation
GO:0048146	IDA:UniProtKB	P	positive regulation of fibroblast proliferation
GO:0050729	IMP:BHF-UCL	P	positive regulation of inflammatory response
GO:0032729	IEA:Ensembl	P	positive regulation of interferon-gamma production
GO:0050718	IMP:BHF-UCL	P	positive regulation of interleukin-1 beta secretion
GO:0032755	IMP:BHF-UCL	P	positive regulation of interleukin-6 production
GO:2000484	IEA:Ensembl	P	positive regulation of interleukin-8 secretion
GO:0043032	IMP:BHF-UCL	P	positive regulation of macrophage activation
GO:0060907	IMP:UniProtKB	P	positive regulation of macrophage cytokine production
GO:0045836	IEA:Ensembl	P	positive regulation of meiosis
GO:0002053	IEA:Ensembl	P	positive regulation of mesenchymal cell proliferation
GO:0010976	ISS:UniProtKB	P	positive regulation of neuron projection development
GO:0051092	IDA:UniProtKB	P	positive regulation of NF-kappaB transcription factor activity
GO:0045778	IMP:BHF-UCL	P	positive regulation of ossification
GO:0033138	IEA:Ensembl	P	positive regulation of peptidyl-serine phosphorylation
GO:0010800	IEA:Ensembl	P	positive regulation of peptidyl-threonine phosphorylation
GO:0045732	IGI:MGI	P	positive regulation of protein catabolic process
GO:0090037	IMP:UniProtKB	P	positive regulation of protein kinase C signaling
GO:0060760	IDA:UniProtKB	P	positive regulation of response to cytokine stimulus
GO:0010820	IMP:UniProtKB	P	positive regulation of T cell chemotaxis
GO:0070245	IEA:Ensembl	P	positive regulation of thymocyte apoptotic process
GO:0045893	IMP:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0045944	IMP:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:0060340	IDA:BHF-UCL	P	positive regulation of type I interferon-mediated signaling pathway
GO:0036342	IEA:Ensembl	P	post-anal tail morphogenesis
GO:0090009	IEA:Ensembl	P	primitive streak formation
GO:0006468	IEA:Ensembl	P	protein phosphorylation
GO:0060762	IEA:Ensembl	P	regulation of branching involved in mammary gland duct morphogenesis
GO:0010033	IEP:UniProtKB	P	response to organic substance
GO:0001756	IEA:Ensembl	P	somitogenesis
GO:0003323	IEA:Ensembl	P	type B pancreatic cell development
GO:0060157	IEA:Ensembl	P	urinary bladder development
GO:0060065	IEA:Ensembl	P	uterus development
GO:0060068	IEA:Ensembl	P	vagina development
GO:0016055	IDA:BHF-UCL	P	Wnt signaling pathway
GO:0007223	IMP:UniProtKB	P	Wnt signaling pathway, calcium modulating pathway
GO:0042060	IDA:UniProtKB	P	wound healing

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_264478	Asymmetric localization of PCP proteins
REACT_264224	beta-catenin independent WNT signaling
REACT_263982	Ca2+ pathway
REACT_18372	Class B/2 (Secretin family receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_264594	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264383	negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_264199	PCP/CE pathway
REACT_264378	RNF mutants show enhanced WNT signaling and proliferation
REACT_14797	Signaling by GPCR
REACT_11045	Signaling by Wnt
REACT_264125	Signaling by WNT in cancer
REACT_111102	Signal Transduction
REACT_264596	TCF dependent signaling in response to WNT
REACT_264533	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
REACT_263890	WNT5A-dependent internalization of FZD4
REACT_163710	WNT ligand biogenesis and trafficking
REACT_263933	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
REACT_264356	XAV939 inhibits tankyrase, stabilizing AXIN