MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003329

Ontology/Pathway Information

Entrez Gene ID7498
Gene Namexanthine dehydrogenase
Gene Symbol XDH
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IBA:GO_CentralCcytosol
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005777 IEA:UniProtKB-SubCellCperoxisome
GO:0051537 IDA:UniProtKBF2 iron, 2 sulfur cluster binding
GO:0009055 IEA:InterProFelectron carrier activity
GO:0050660 IDA:UniProtKBFflavin adenine dinucleotide binding
GO:0005506 IEA:InterProFiron ion binding
GO:0043546 IDA:UniProtKBFmolybdopterin cofactor binding
GO:0016903 IBA:GO_CentralFoxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0008762 IEA:InterProFUDP-N-acetylmuramate dehydrogenase activity
GO:0004854 IDA:UniProtKBFxanthine dehydrogenase activity
GO:0004855 IDA:UniProtKBFxanthine oxidase activity
GO:0006919 IDA:UniProtKBPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007595 IEA:EnsemblPlactation
GO:0045602 IDA:UniProtKBPnegative regulation of endothelial cell differentiation
GO:0001937 IDA:UniProtKBPnegative regulation of endothelial cell proliferation
GO:0010629 IDA:UniProtKBPnegative regulation of gene expression
GO:0051898 IDA:UniProtKBPnegative regulation of protein kinase B signaling
GO:0001933 IDA:UniProtKBPnegative regulation of protein phosphorylation
GO:1900747 IDA:UniProtKBPnegative regulation of vascular endothelial growth factor signaling pathway
GO:2001213 IDA:UniProtKBPnegative regulation of vasculogenesis
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:1900745 IDA:UniProtKBPpositive regulation of p38MAPK cascade
GO:2000379 IDA:UniProtKBPpositive regulation of reactive oxygen species metabolic process
GO:0006144 TAS:ReactomePpurine nucleobase metabolic process
GO:0006195 TAS:ReactomePpurine nucleotide catabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0009115 IDA:UniProtKBPxanthine catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_2086Purine catabolism
REACT_522Purine metabolism
SMP Pathway Links
SMP IDDescription
SMP00535Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144Adenosine Deaminase Deficiency
SMP00167Adenylosuccinate Lyase Deficiency
SMP00168AICA-Ribosiduria
SMP00427Azathioprine Action Pathway
SMP00028Caffeine Metabolism
SMP00650Doxorubicin Metabolism Pathway
SMP00365Gout or Kelley-Seegmiller Syndrome
SMP00364Lesch-Nyhan Syndrome (LNS)
SMP00428Mercaptopurine Action Pathway
SMP00609Mercaptopurine Metabolism Pathway
SMP00536Mitochondrial DNA depletion syndrome
SMP00203Molybdenum Cofactor Deficiency
SMP00537Myoadenylate deaminase deficiency
SMP00050Purine Metabolism
SMP00210Purine Nucleoside Phosphorylase Deficiency
SMP00430Thioguanine Action Pathway
SMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512Xanthinuria type I
SMP00513Xanthinuria type II
  logo