MGP Database

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MGP003330

Record overview

MGPD IDMGP003330
Gene ID7507
SpeciesHomo sapiens (Human)
Gene Namexeroderma pigmentosum, complementation group A
Gene Symbol XPA
SynonymsXP1; XPAC;
Alternate namesDNA repair protein complementing XP-A cells; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein;
Chromosome9
Map Location9q22.3
SummaryThis gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for XPA

Proteins

DNA repair protein complementing XP-A cells
Refseq ID:NP_000371
Protein GI:4507937
UniProt ID:P23025
mRNA ID:NM_000380
Length:273
RefSeq Status:
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMANVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEF
DYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEAL
EEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
 
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