MGP Database

MGP003419

Record overview

MGPD ID	MGP003419
Gene ID	7850
Species	Homo sapiens (Human)
Gene Name	interleukin 1 receptor, type II
Gene Symbol	IL1R2
Synonyms	IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2;
Alternate names	interleukin-1 receptor type 2; CD121 antigen-like family member B; IL-1 type II receptor; IL-1R-beta; antigen CDw121b; interleukin 1 receptor type II variant 3; interleukin-1 receptor beta; interleukin-1 receptor type II; type II interleukin-1 receptor, beta;
Chromosome	2
Map Location	2q12
Summary	The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Orthologs	View orthologs and multiple alignments for IL1R2

Proteins

interleukin-1 receptor type 2 isoform 1 precursor

Refseq ID:	NP_004624
Protein GI:	4758598
UniProt ID:	P27930
mRNA ID:	NM_004633
Length:	398
RefSeq Status:

MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ
EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALE
DAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE
NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK

sig_peptide: 1..13
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1452
peptide sequence: 
MLRLYVLVMGVSA

mat_peptide: 14..296
product: interleukin-1 receptor type 2 isoform 2
calculated_mol_wt: 32188
peptide sequence: 
FTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNA
SYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAH
EGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQ

sig_peptide: 1..13
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1452
peptide sequence: 
MLRLYVLVMGVSA

mat_peptide: 14..398
product: interleukin-1 receptor type 2 isoform 1
calculated_mol_wt: 43987
peptide sequence: 
FTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNA
SYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAH
EGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFD
PVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK

interleukin-1 receptor type 2 isoform 2 precursor

Refseq ID:	NP_001248348
Protein GI:	387527984
UniProt ID:	P27930
mRNA ID:	NM_001261419
Length:	296
RefSeq Status:

`MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALE DAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQ`

sig_peptide: 1..13
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1452
peptide sequence: 
MLRLYVLVMGVSA

mat_peptide: 14..296
product: interleukin-1 receptor type 2 isoform 2
calculated_mol_wt: 32188
peptide sequence: 
FTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNA
SYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAH
EGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQ