MGP Database

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MGP003420

Ontology/Pathway Information

Entrez Gene ID7852
Gene Namechemokine (C-X-C motif) receptor 4
Gene Symbol CXCR4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0031252 IDA:UniProtKBCcell leading edge
GO:0009986 IDA:UniProtKBCcell surface
GO:0005737 TAS:ProtIncCcytoplasm
GO:0016023 IDA:UniProtKBCcytoplasmic membrane-bounded vesicle
GO:0031410 IDA:UniProtKBCcytoplasmic vesicle
GO:0005769 IDA:UniProtKBCearly endosome
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0030426 IEA:EnsemblCgrowth cone
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005770 IDA:UniProtKBClate endosome
GO:0005764 IDA:UniProtKBClysosome
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0003779 IDA:UniProtKBFactin binding
GO:0015026 TAS:ProtIncFcoreceptor activity
GO:0016494 NAS:UniProtKBFC-X-C chemokine receptor activity
GO:0004930 TAS:ProtIncFG-protein coupled receptor activity
GO:0032027 IDA:UniProtKBFmyosin light chain binding
GO:0043130 IDA:UniProtKBFubiquitin binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0001618 IEA:UniProtKB-KWFvirus receptor activity
GO:0000187 TAS:ProtIncPactivation of MAPK activity
GO:0001667 IEA:EnsemblPameboidal-type cell migration
GO:0006915 TAS:ProtIncPapoptotic process
GO:0007420 IEA:EnsemblPbrain development
GO:0019722 IMP:MGIPcalcium-mediated signaling
GO:0071345 IDA:UniProtKBPcellular response to cytokine stimulus
GO:0070098 NAS:GOCPchemokine-mediated signaling pathway
GO:0002407 TAS:BHF-UCLPdendritic cell chemotaxis
GO:0030260 TAS:ReactomePentry into host cell
GO:0007281 IEA:EnsemblPgerm cell development
GO:0008354 IEA:EnsemblPgerm cell migration
GO:0007186 IDA:UniProtKBPG-protein coupled receptor signaling pathway
GO:0006954 TAS:ProtIncPinflammatory response
GO:0008045 IEA:EnsemblPmotor neuron axon guidance
GO:0043217 ISS:BHF-UCLPmyelin maintenance
GO:0061351 IEA:EnsemblPneural precursor cell proliferation
GO:0001764 IEA:EnsemblPneuron migration
GO:0042119 IEA:InterProPneutrophil activation
GO:0001569 IEA:EnsemblPpatterning of blood vessels
GO:0007204 TAS:ProtIncPpositive regulation of cytosolic calcium ion concentration
GO:0048714 ISS:BHF-UCLPpositive regulation of oligodendrocyte differentiation
GO:0030334 IEA:EnsemblPregulation of cell migration
GO:0050920 IMP:UniProtKBPregulation of chemotaxis
GO:0001666 IEP:UniProtKBPresponse to hypoxia
GO:0009615 TAS:ProtIncPresponse to virus
GO:0042098 IEA:EnsemblPT cell proliferation
GO:0016032 TAS:ReactomePviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6903Binding and entry of HIV virion
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_6266Early Phase of HIV Life Cycle
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_6185HIV Infection
REACT_6256HIV Life Cycle
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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