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MGP003423

Record overview

MGPD IDMGP003423
Gene ID7867
SpeciesHomo sapiens (Human)
Gene Namemitogen-activated protein kinase-activated protein kinase 3
Gene Symbol MAPKAPK3
Synonyms3PK; MK-3; MAPKAP3; MAPKAP-K3; MAPKAPK-3;
Alternate namesMAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; chromosome 3p kinase;
Chromosome3
Map Location3p21.3
EC Number2.7.11.1
SummaryThis gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for MAPKAPK3

Proteins

MAP kinase-activated protein kinase 3
Refseq ID:NP_001230854
Protein GI:345441756
UniProt ID:Q16644
mRNA ID:NM_001243925
Length:382
RefSeq Status:
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCI
LDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQ
TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
 
MAP kinase-activated protein kinase 3
Refseq ID:NP_001230855
Protein GI:345441758
UniProt ID:Q16644
mRNA ID:NM_001243926
Length:382
RefSeq Status:
Protein sequence is identical to GI:345441756 (mRNA isoform)
 
MAP kinase-activated protein kinase 3
Refseq ID:NP_004626
Protein GI:4758700
UniProt ID:Q16644
mRNA ID:NM_004635
Length:382
RefSeq Status:
Protein sequence is identical to GI:345441756 (mRNA isoform)
 
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