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MGP003425

UniProt Annotations

Entry Information
Gene Namepotassium channel, voltage gated subfamily A regulatory beta subunit 1
Protein EntryKCAB1_HUMAN
UniProt IDQ14722
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=KvB1.3; IsoId=Q14722-1; Sequence=Displayed; Name=KvB1.1; IsoId=Q14722-2; Sequence=VSP_001051; Name=KvB1.2; IsoId=Q14722-3; Sequence=VSP_001050; Note=Ref.9 (AAC50113) sequence is in conflict in position: 16:L->S. {ECO:0000305};
DomainAlteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit. {ECO:0000305}.
FunctionAccessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.
SimilarityBelongs to the shaker potassium channel beta subunit family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000305}.
SubunitForms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1 (By similarity). {ECO:0000250}.
Tissue SpecificityIn brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. {ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:8938711}.
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