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MGP003432

Record overview

MGPD IDMGP003432
Gene ID7941
SpeciesHomo sapiens (Human)
Gene Namephospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Gene Symbol PLA2G7
SynonymsPAFAD; PAFAH; LP-PLA2; LDL-PLA2;
Alternate namesplatelet-activating factor acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; LDL-PLA(2); LDL-associated phospholipase A2; PAF 2-acylhydrolase; PAF acetylhydrolase; gVIIA-PLA2; group-VIIA phospholipase A2; lipoprotein-associated phospholipase A2;
Chromosome6
Map Location6p21.2-p12
EC Number3.1.1.47
SummaryThe protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
OrthologsView orthologs and multiple alignments for PLA2G7

Proteins

platelet-activating factor acetylhydrolase precursor
Refseq ID:NP_005075
Protein GI:189095271
UniProt ID:Q13093
mRNA ID:NM_005084
Length:441
RefSeq Status:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPN
KEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGD
KSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHK
DFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
 
sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2303
peptide sequence: 
MVPPKLHVLFCLCGCLAVVYP

mat_peptide: 22..441
product: platelet-activating factor acetylhydrolase
calculated_mol_wt: 47793
peptide sequence: 
FDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNIL
RLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQ
VRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEY
FQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTN
INTTNQHIMLQNSSGIEKYN

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2303
peptide sequence: 
MVPPKLHVLFCLCGCLAVVYP
 
platelet-activating factor acetylhydrolase precursor
Refseq ID:NP_001161829
Protein GI:270133071
UniProt ID:Q13093
mRNA ID:NM_001168357
Length:441
RefSeq Status:
Protein sequence is identical to GI:189095271 (mRNA isoform)
 
sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2303
peptide sequence: 
MVPPKLHVLFCLCGCLAVVYP

mat_peptide: 22..441
product: platelet-activating factor acetylhydrolase
calculated_mol_wt: 47793
peptide sequence: 
FDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNIL
RLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQ
VRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEY
FQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTN
INTTNQHIMLQNSSGIEKYN
 
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