MGP Database

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MGP003462

UniProt Annotations

Entry Information
Gene NameA kinase (PRKA) anchor protein 1
Protein EntryAKAP1_HUMAN
UniProt IDQ92667
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=AKAP149; IsoId=Q92667-1; Sequence=Displayed; Name=2; Synonyms=S-AKAP84; IsoId=Q92667-2; Sequence=VSP_002845, VSP_002846; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
DomainRII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
FunctionBinds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
InteractionQ7Z4T9-4:MAATS1; NbExp=3; IntAct=EBI-2120060, EBI-2119735; Q99417:MYCBP; NbExp=2; IntAct=EBI-2120060, EBI-716185; P13861:PRKAR2A; NbExp=3; IntAct=EBI-2119593, EBI-2556122;
SimilarityContains 1 KH domain. {ECO:0000255|PROSITE- ProRule:PRU00117}.
SimilarityContains 1 Tudor domain. {ECO:0000255|PROSITE- ProRule:PRU00211}.
Subcellular LocationMitochondrion outer membrane {ECO:0000305}.
Tissue SpecificityAKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma.
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