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MGP003463

UniProt Annotations

Entry Information
Gene Namesolute carrier family 14 (urea transporter), member 2
Protein EntryUT2_HUMAN
UniProt IDQ15849
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=UT-A1; IsoId=Q15849-1; Sequence=Displayed; Name=2; Synonyms=UT-A2; IsoId=Q15849-2; Sequence=VSP_031171;
FunctionSpecialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. {ECO:0000269|PubMed:11502588, ECO:0000269|PubMed:8647271}.
InductionIsoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration.
InteractionO95295:SNAPIN; NbExp=5; IntAct=EBI-1633392, EBI-296723;
SimilarityBelongs to the urea transporter family. {ECO:0000305}.
Subcellular LocationApical cell membrane; Multi-pass membrane protein.
SubunitIsoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane. {ECO:0000269|PubMed:17702749}.
Tissue SpecificityIsoform 1 and isoform 2 are expressed in the inner medulla of the kidney. {ECO:0000269|PubMed:11502588, ECO:0000269|PubMed:8647271}.
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