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MGP003474

UniProt Annotations

Entry Information
Gene Namelysine (K)-specific demethylase 5D
Protein EntryKDM5D_HUMAN
UniProt IDQ9BY66
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9BY66-1; Sequence=Displayed; Name=2; IsoId=Q9BY66-2; Sequence=VSP_000317; Name=3; IsoId=Q9BY66-3; Sequence=VSP_043320; Note=No experimental confirmation available.;
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000269|PubMed:17320162}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000269|PubMed:17320162};
CofactorName=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence={ECO:0000269|PubMed:17320162};
DomainThe JmjC domain is required for enzymatic activity.
FunctionHistone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. {ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:17351630}.
Sequence CautionSequence=BAA13241.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the JARID1 histone demethylase family. {ECO:0000305}.
SimilarityContains 1 ARID domain. {ECO:0000255|PROSITE- ProRule:PRU00355}.
SimilarityContains 1 JmjC domain. {ECO:0000255|PROSITE- ProRule:PRU00538}.
SimilarityContains 1 JmjN domain. {ECO:0000255|PROSITE- ProRule:PRU00537}.
SimilarityContains 2 PHD-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00146}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitInteracts with PCGF6 and MSH5. {ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:18459961}.
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