MGP Database

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MGP003480

UniProt Annotations

Entry Information
Gene Nameacyl-CoA oxidase 2, branched chain
Protein EntryACOX2_HUMAN
UniProt IDQ99424
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5- beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3- alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionOxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.
SimilarityBelongs to the acyl-CoA oxidase family. {ECO:0000305}.
Subcellular LocationPeroxisome.
SubunitHeterodimer. {ECO:0000250}.
Tissue SpecificityPresent in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.
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