MGP Database

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MGP003488

Ontology/Pathway Information

Entrez Gene ID8323
Gene Namefrizzled class receptor 6
Gene Symbol FZD6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 IEA:EnsemblCapical part of cell
GO:0016327 IEA:EnsemblCapicolateral plasma membrane
GO:0016021 IBA:GO_CentralCintegral component of membrane
GO:0005887 ISS:BHF-UCLCintegral component of plasma membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0004930 IBA:GO_CentralFG-protein coupled receptor activity
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0042813 IDA:BHF-UCLFWnt-activated receptor activity
GO:0017147 ISS:BHF-UCLFWnt-protein binding
GO:0033278 IEA:EnsemblPcell proliferation in midbrain
GO:0035880 IEA:EnsemblPembryonic nail plate morphogenesis
GO:0001736 IEA:EnsemblPestablishment of planar polarity
GO:0001942 IEA:EnsemblPhair follicle development
GO:0042472 IEA:EnsemblPinner ear morphogenesis
GO:0090090 IMP:BHF-UCLPnegative regulation of canonical Wnt signaling pathway
GO:0043433 IDA:BHF-UCLPnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0001843 IEA:EnsemblPneural tube closure
GO:0035567 IDA:BHF-UCLPnon-canonical Wnt signaling pathway
GO:0030168 IEA:EnsemblPplatelet activation
GO:0060071 IEA:EnsemblPWnt signaling pathway, planar cell polarity pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_18372Class B/2 (Secretin family receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264199PCP/CE pathway
REACT_264580regulation of FZD by ubiquitination
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_14797Signaling by GPCR
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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