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MGP003491

UniProt Annotations

Entry Information
Gene Namefrizzled class receptor 9
Protein EntryFZD9_HUMAN
UniProt IDO00144
SpeciesHuman
Comments
Comment typeDescription
CautionHas been first described as FZD3 in literature. {ECO:0000305}.
DomainLys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. {ECO:0000250}.
DomainThe FZ domain is involved in binding with Wnt ligands. {ECO:0000250}.
FunctionReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
PtmUbiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
SimilarityBelongs to the G-protein coupled receptor Fz/Smo family. {ECO:0000305}.
SimilarityContains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE- ProRule:PRU00090}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityExpressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.
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