MGP Database

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MGP003542

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-5-phosphate 4-kinase, type II, beta
Protein EntryPI42B_HUMAN
UniProt IDP78356
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78356-1; Sequence=Displayed; Name=2; IsoId=P78356-2; Sequence=VSP_010384, VSP_010385; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate {ECO:0000269|PubMed:20583997}; Vmax=0.2 pmol/min/ug enzyme {ECO:0000269|PubMed:20583997};
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
FunctionParticipates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:9038203}.
PtmUbiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. {ECO:0000269|PubMed:20583997}.
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
SubunitHomodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. {ECO:0000269|PubMed:20583997, ECO:0000269|PubMed:9038203}.
Tissue SpecificityHighly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. {ECO:0000269|PubMed:9038203}.
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