MGP Database

MGP003543

Ontology/Pathway Information

Entrez Gene ID	8398
Gene Name	phospholipase A2, group VI (cytosolic, calcium-independent)
Gene Symbol	PLA2G6
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0016020	IEA:UniProtKB-SubCell	C	membrane
GO:0005815	IDA:HPA	C	microtubule organizing center
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0047499	IEA:Ensembl	F	calcium-independent phospholipase A2 activity
GO:0004623	TAS:ProtInc	F	phospholipase A2 activity
GO:0035965	TAS:Reactome	P	cardiolipin acyl-chain remodeling
GO:0032049	IMP:UniProtKB	P	cardiolipin biosynthetic process
GO:0006935	IEA:UniProtKB-KW	P	chemotaxis
GO:0038096	TAS:Reactome	P	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0046474	TAS:Reactome	P	glycerophospholipid biosynthetic process
GO:0045087	TAS:Reactome	P	innate immune response
GO:0016042	IEA:UniProtKB-KW	P	lipid catabolic process
GO:0060135	IEA:Ensembl	P	maternal process involved in female pregnancy
GO:0007613	IEA:Ensembl	P	memory
GO:0051967	IEA:Ensembl	P	negative regulation of synaptic transmission, glutamatergic
GO:0036151	TAS:Reactome	P	phosphatidylcholine acyl-chain remodeling
GO:0036152	TAS:Reactome	P	phosphatidylethanolamine acyl-chain remodeling
GO:0006644	TAS:Reactome	P	phospholipid metabolic process
GO:0090238	IEA:Ensembl	P	positive regulation of arachidonic acid secretion
GO:2000304	IEA:Ensembl	P	positive regulation of ceramide biosynthetic process
GO:0007204	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration
GO:0045921	IEA:Ensembl	P	positive regulation of exocytosis
GO:0035774	IEA:Ensembl	P	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0090037	IEA:Ensembl	P	positive regulation of protein kinase C signaling
GO:0001934	IEA:Ensembl	P	positive regulation of protein phosphorylation
GO:0090200	IEA:Ensembl	P	positive regulation of release of cytochrome c from mitochondria
GO:0045909	IEA:Ensembl	P	positive regulation of vasodilation
GO:1901339	IEA:Ensembl	P	regulation of store-operated calcium channel activity
GO:0034976	IEA:Ensembl	P	response to endoplasmic reticulum stress
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0014832	IEA:Ensembl	P	urinary bladder smooth muscle contraction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_121006	Acyl chain remodeling of CL
REACT_120829	Acyl chain remodelling of PC
REACT_121369	Acyl chain remodelling of PE
REACT_160123	Fcgamma receptor (FCGR) dependent phagocytosis
REACT_121401	Glycerophospholipid biosynthesis
REACT_6900	Immune System
REACT_6802	Innate Immune System
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_120870	Phospholipid metabolism
REACT_160158	Role of phospholipids in phagocytosis