MGP Database

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MGP003545

UniProt Annotations

Entry Information
Gene Namesolute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
Protein Entry
UniProt IDQ6IBH0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02978-1; Sequence=Displayed; Name=2; IsoId=Q02978-2; Sequence=VSP_046745; Note=Gene prediction based on EST data.;
FunctionCatalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
SimilarityBelongs to the mitochondrial carrier (TC 2.A.29) family. {ECO:0000305}.
SimilarityContains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule:PRU00282}.
Subcellular LocationMitochondrion inner membrane; Multi-pass membrane protein.
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