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MGP003565

Record overview

MGPD IDMGP003565
Gene ID8480
SpeciesHomo sapiens (Human)
Gene Nameribonucleic acid export 1
Gene Symbol RAE1
SynonymsMIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1;
Alternate namesmRNA export factor; RAE1 RNA export 1 homolog; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer); mRNA export protein; mRNA-associated protein MRNP 41; mRNA-binding protein, 41-kD; migration-inducing gene 14; rae1 protein homolog;
Chromosome20
Map Location20q13.31
SummaryMutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RAE1

Proteins

mRNA export factor
Refseq ID:NP_003601
Protein GI:4506399
UniProt ID:P78406
mRNA ID:NM_003610
Length:368
RefSeq Status:
MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSK
VFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQ
PSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFW
DKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK
 
mRNA export factor
Refseq ID:NP_001015885
Protein GI:62739173
UniProt ID:P78406
mRNA ID:NM_001015885
Length:368
RefSeq Status:
Protein sequence is identical to GI:4506399 (mRNA isoform)
 
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