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MGP003583

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, zeta
Protein EntryDGKZ_HUMAN
UniProt IDQ13574
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=1; Synonyms=Long, zeta2; IsoId=Q13574-1; Sequence=Displayed; Note=Minor isoform.; Name=2; Synonyms=Short; IsoId=Q13574-2; Sequence=VSP_001268; Note=Major isoform.; Name=3; IsoId=Q13574-3; Sequence=VSP_043163, VSP_043164; Note=No experimental confirmation available.; Name=4; IsoId=Q13574-4; Sequence=VSP_001268, VSP_045628; Note=No experimental confirmation available.; Name=5; IsoId=Q13574-5; Sequence=VSP_001268, VSP_045628, VSP_046920; Note=No experimental confirmation available.; Name=6; IsoId=Q13574-6; Sequence=VSP_001268, VSP_045628, VSP_046919; Note=No experimental confirmation available.; Name=7; IsoId=Q13574-7; Sequence=VSP_055147, VSP_055148, VSP_045628; Note=No experimental confirmation available.;
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
FunctionDisplays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. {ECO:0000269|PubMed:11257115}.
InteractionP06400:RB1; NbExp=6; IntAct=EBI-715527, EBI-491274; P28749:RBL1; NbExp=2; IntAct=EBI-715527, EBI-971402; Q08999:RBL2; NbExp=2; IntAct=EBI-715527, EBI-971439;
PtmPhosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta. {ECO:0000269|PubMed:9716136}.
Sequence CautionSequence=AAB60859.1; Type=Frameshift; Positions=166, 167; Evidence={ECO:0000305};
SimilarityBelongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Cell membrane.
SubunitInteracts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS. {ECO:0000269|PubMed:11257115, ECO:0000269|PubMed:11352924, ECO:0000269|PubMed:17351151}.
Tissue SpecificityHighest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.
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