MGP Database

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MGP003585

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, delta 130kDa
Protein EntryDGKD_HUMAN
UniProt IDQ16760
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q16760-1; Sequence=Displayed; Name=1; IsoId=Q16760-2; Sequence=VSP_012891;
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationPartially inhibited by phosphatidylserine.
FunctionIsoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis. {ECO:0000269|PubMed:17880279}.
FunctionMay function as signaling molecule. {ECO:0000269|PubMed:17880279}.
InteractionO75923:DYSF; NbExp=3; IntAct=EBI-719333, EBI-2799016;
PtmIsoform 1 H domain is phosphorylated. {ECO:0000269|PubMed:12084710}.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
Subcellular LocationIsoform 1: Membrane; Peripheral membrane protein.
Subcellular LocationIsoform 2: Cytoplasm.
SubunitThe two isoforms are able to form homo- and hetero- oligomer structures (at least tetramers). Isoform 2 interacts with AP2A2. {ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279}.
Tissue SpecificityIsoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells. {ECO:0000269|PubMed:12200442}.
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