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MGP003588

UniProt Annotations

Entry Information
Gene Namecarbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Protein EntryCHST1_HUMAN
UniProt IDO43916
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. {ECO:0000269|PubMed:9405439}.
CautionWas originally (PubMed:9639683) thought to be the ortholog of chicken CHST3 and therefore named C6ST. However, it has no strong chondroitin 6-sulfotransferase activity. {ECO:0000305|PubMed:9639683}.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612}.
SimilarityBelongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue SpecificityWidely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9405439}.
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CHST1";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/chst1/";
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