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MGP003602

Record overview

MGPD IDMGP003602
Gene ID8560
SpeciesHomo sapiens (Human)
Gene Namedelta(4)-desaturase, sphingolipid 1
Gene Symbol DEGS1
SynonymsMLD; DEGS; DES1; Des-1; FADS7; MIG15; DEGS-1;
Alternate namessphingolipid delta(4)-desaturase DES1; cell migration-inducing gene 15 protein; degenerative spermatocyte homolog 1, lipid desaturase; degenerative spermatocyte homolog, lipid desaturase; dihydroceramide desaturase 1; membrane fatty acid (lipid) desaturase; membrane lipid desaturase; migration-inducing gene 15 protein; sphingolipid delta 4 desaturase; sphingolipid delta(4)-desaturase 1;
Chromosome1
Map Location1q42.11
EC Number1.14.-.-
SummaryThis gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for DEGS1

Proteins

sphingolipid delta(4)-desaturase DES1
Refseq ID:NP_003667
Protein GI:4505193
UniProt ID:O15121
mRNA ID:NM_003676
Length:323
RefSeq Status:
MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNC
KAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILI
YYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDF
VMDDTISPYSRMKRHQKGEMVLE
 
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