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MGP003603

Record overview

MGPD IDMGP003603
Gene ID8564
SpeciesHomo sapiens (Human)
Gene Namekynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Gene Symbol KMO
SynonymsdJ317G22.1;
Alternate nameskynurenine 3-monooxygenase; KMO; kynurenine 3-hydroxylase;
Chromosome1
Map Location1q42-q44
EC Number1.14.13.9
SummaryThis gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for KMO

Proteins

kynurenine 3-monooxygenase
Refseq ID:NP_003670
Protein GI:187960045
UniProt ID:O15229
mRNA ID:NM_003679
Length:486
RefSeq Status:
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYG
TKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIP
PKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTM
VTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR
 
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