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MGP003606

UniProt Annotations

Entry Information
Gene NameMAP kinase interacting serine/threonine kinase 1
Protein EntryMKNK1_HUMAN
UniProt IDQ9BUB5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1 {ECO:0000269|PubMed:11463832}; IsoId=Q9BUB5-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:9155018}; Synonyms=MNK1a; IsoId=Q9BUB5-2; Sequence=VSP_007352; Name=3; Synonyms=MNK1b; IsoId=Q9BUB5-3; Sequence=VSP_007352, VSP_017515;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:9155018}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:9155018};
Enzyme RegulationPhosphorylated and activated by the p38 kinases and kinases in the Erk pathway. {ECO:0000269|PubMed:9155018}.
FunctionMay play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}.
InteractionQ16539:MAPK14; NbExp=3; IntAct=EBI-73837, EBI-73946;
PtmDual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:9155018}.
SimilarityBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationIsoform 2: Cytoplasm.
Subcellular LocationIsoform 3: Cytoplasm. Nucleus.
SubunitInteracts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases. {ECO:0000269|PubMed:9878069}.
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:15350534}.
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