MGP Database

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MGP003614

Record overview

MGPD IDMGP003614
Gene ID8604
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 25 (aspartate/glutamate carrier), member 12
Gene Symbol SLC25A12
SynonymsAGC1; ARALAR;
Alternate namescalcium-binding mitochondrial carrier protein Aralar1; araceli hiperlarga; calcium binding mitochondrial carrier superfamily member Aralar1; mitochondrial aspartate glutamate carrier 1; solute carrier family 25 (mitochondrial carrier, Aralar), member 12;
Chromosome2
Map Location2q24
SummaryThis gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
OrthologsView orthologs and multiple alignments for SLC25A12

Proteins

calcium-binding mitochondrial carrier protein Aralar1
Refseq ID:NP_003696
Protein GI:21361103
UniProt ID:O75746
mRNA ID:NM_003705
Length:678
RefSeq Status:
MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDK
SGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEE
NLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGAL
PYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVA
PEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFP
VYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYEL
LQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ
 
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