MGP Database

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MGP003615

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IVC (cytosolic, calcium-independent)
Protein EntryPA24C_HUMAN
UniProt IDQ9UP65
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UP65-1; Sequence=Displayed; Name=2; IsoId=Q9UP65-2; Sequence=VSP_045850; Name=3; IsoId=Q9UP65-3; Sequence=VSP_045849;
Biophysicochemical PropertiesKinetic parameters: Vmax=218 pmol/min/mg enzyme {ECO:0000269|PubMed:10085124};
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Enzyme RegulationNot regulated by calcium.
FunctionHas a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. {ECO:0000269|PubMed:10085124}.
SimilarityContains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular LocationMembrane {ECO:0000269|PubMed:10085124}; Lipid-anchor {ECO:0000269|PubMed:10085124}.
Tissue SpecificityHighly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:9705332}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g4c/";
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