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MGP003617

UniProt Annotations

Entry Information
Gene Nameretinol dehydrogenase 16 (all-trans)
Protein EntryRDH16_HUMAN
UniProt IDO75452
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.14 uM for androsterone {ECO:0000269|PubMed:9677409}; KM=0.22 uM for androstanediol {ECO:0000269|PubMed:9677409}; KM=0.80 uM for dihydrotestosterone {ECO:0000269|PubMed:9677409}; KM=0.13 uM for NAD {ECO:0000269|PubMed:9677409}; KM=190 uM for NADP {ECO:0000269|PubMed:9677409};
Enzyme RegulationInhibited by citral, perillyl alcohol, geraniol, farnesol and geranyl geraniol. {ECO:0000269|PubMed:9677409}.
FunctionOxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:9677409}.
InductionTransiently up-regulated by retinoic acid. {ECO:0000269|PubMed:10329026}.
PtmNot N-glycosylated.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMicrosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Tissue SpecificityHighly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:11967490, ECO:0000269|PubMed:9677409}.
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