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MGP003626

UniProt Annotations

Entry Information
Gene Nameamine oxidase, copper containing 3
Protein EntryAOC3_HUMAN
UniProt IDQ16853
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16853-1; Sequence=Displayed; Name=2; Synonyms=VAP-1Delta3; IsoId=Q16853-2; Sequence=VSP_053751, VSP_053752; Note=Devoid of the semicarbazide-sensitive amine oxidase (SSAO) activity.; Name=3; IsoId=Q16853-3; Sequence=VSP_055201; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=1.94 mM for 2-phenylethylamine {ECO:0000269|PubMed:19588076}; KM=0.67 mM for methylamine {ECO:0000269|PubMed:19588076};
Catalytic ActivityRCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
CofactorName=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds 1 copper ion per subunit.;
CofactorName=L-topaquinone; Xref=ChEBI:CHEBI:79027; Note=Contains 1 topaquinone per subunit.;
FunctionCell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}.
InductionUp-regulated during in vitro adipocyte differentiation. {ECO:0000269|PubMed:17400359}.
PtmN- and O-glycosylated. {ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218}.
PtmTopaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
SimilarityBelongs to the copper/topaquinone oxidase family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}.
SubunitHomodimer; disulfide-linked. Can heterodimerize with isoform 2 leading to reduced surface expression. Forms a heterodimer with AOC2. {ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812}.
Tissue SpecificityStrongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/aoc3/";
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