MGP Database

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MGP003639

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation initiation factor 3, subunit D
Protein EntryEIF3D_HUMAN
UniProt IDO15371
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15371-1; Sequence=Displayed; Name=2; IsoId=O15371-2; Sequence=VSP_055473; Note=No experimental confirmation available.; Name=3; IsoId=O15371-3; Sequence=VSP_055474; Note=No experimental confirmation available.;
FunctionComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
InteractionQ9Q2G4:ORF (xeno); NbExp=5; IntAct=EBI-353818, EBI-6248094; Q8WV24:PHLDA1; NbExp=2; IntAct=EBI-353818, EBI-738731;
Mass SpectrometryMass=63972.9; Method=Unknown; Range=1-548; Evidence={ECO:0000269|PubMed:17322308};
Mass SpectrometryMass=64046.7; Mass_error=1.4; Method=MALDI; Range=1-548; Evidence={ECO:0000269|PubMed:18599441};
SimilarityBelongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-Rule:MF_03003}.
Subcellular LocationCytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
SubunitComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. {ECO:0000255|HAMAP-Rule:MF_03003, ECO:0000269|PubMed:16766523, ECO:0000269|PubMed:17322308, ECO:0000269|PubMed:18599441}.
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