MGP Database

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MGP003647

UniProt Annotations

Entry Information
Gene Namevesicle-associated membrane protein 8
Protein EntryVAMP8_HUMAN
UniProt IDQ9BV40
SpeciesHuman
Comments
Comment typeDescription
FunctionSNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. {ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709}.
SimilarityBelongs to the synaptobrevin family. {ECO:0000305}.
SimilarityContains 1 v-SNARE coiled-coil homology domain. {ECO:0000255|PROSITE-ProRule:PRU00290}.
Subcellular LocationLysosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250}.
SubunitForms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome. Binds tightly to multiple syntaxins. Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B. {ECO:0000269|PubMed:12130530}.
Tissue SpecificityPlatelets.
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