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MGP003666

UniProt Annotations

Entry Information
Gene NameRNA (guanine-7-) methyltransferase
Protein EntryMCES_HUMAN
UniProt IDO43148
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=hCMT1a; IsoId=O43148-1; Sequence=Displayed; Name=2; Synonyms=hCMT1b; IsoId=O43148-2; Sequence=VSP_020241;
Catalytic ActivityS-adenosyl-L-methionine + G(5')pppR-RNA = S- adenosyl-L-homocysteine + m(7)G(5')pppR-RNA. {ECO:0000255|PROSITE- ProRule:PRU00895}.
FunctionmRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}.
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU00895}.
SimilarityContains 1 mRNA cap 0 methyltransferase domain. {ECO:0000255|PROSITE-ProRule:PRU00895}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:15767670}.
SubunitInteracts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT- importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAM/FAM103A1, the interaction significantly enhances RNA-binding and cap methyltransferase activity. {ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:9705270}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}.
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