MGP Database

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MGP003684

UniProt Annotations

Entry Information
Gene Namemyotubularin related protein 1
Protein EntryMTMR1_HUMAN
UniProt IDQ13613
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13613-1; Sequence=Displayed; Name=1A; IsoId=Q13613-2; Sequence=VSP_005169, VSP_005170;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate. {ECO:0000269|PubMed:11733541}.
FunctionLipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol (3,5)-bisphosphate. {ECO:0000269|PubMed:11733541}.
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. {ECO:0000305}.
SimilarityContains 1 GRAM domain. {ECO:0000305}.
SimilarityContains 1 myotubularin phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU00669}.
Subcellular LocationCell membrane {ECO:0000250|UniProtKB:Q9Z2C4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z2C4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z2C4}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z2C4}.
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