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MGP003706

UniProt Annotations

Entry Information
Gene Namecarboxylesterase 2
Protein EntryEST2_HUMAN
UniProt IDO00748
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00748-1; Sequence=Displayed; Name=2; IsoId=O00748-2; Sequence=VSP_010161;
Biophysicochemical PropertiesKinetic parameters: KM=0.39 mM for cocaine {ECO:0000269|PubMed:9169443}; KM=0.15 mM for 4-methylumbelliferyl acetate {ECO:0000269|PubMed:9169443}; KM=6.8 mM for heroin {ECO:0000269|PubMed:9169443}; KM=0.13 mM for 6-monoacetylmorphine {ECO:0000269|PubMed:9169443};
Catalytic Activity4-methylumbelliferyl acetate + H(2)O = 4- methylumbelliferone + acetate. {ECO:0000269|PubMed:9169443}.
Catalytic ActivityA carboxylic ester + H(2)O = an alcohol + a carboxylate. {ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:9169443}.
Catalytic ActivityCocaine + H(2)O = ecgonine methyl ester + benzoate. {ECO:0000269|PubMed:9169443}.
FunctionInvolved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. {ECO:0000269|PubMed:9169443}.
PtmGlycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9169443}.
Sequence CautionSequence=AAH32095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAW29943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD28531.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD98009.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the type-B carboxylesterase/lipase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum lumen {ECO:0000250}.
SubunitMonomer. {ECO:0000269|PubMed:9169443}.
Tissue SpecificityPreferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. {ECO:0000269|PubMed:9144407}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ces2/";
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