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MGP003717

UniProt Annotations

Entry Information
Gene NameK(lysine) acetyltransferase 2B
Protein EntryKAT2B_HUMAN
UniProt IDQ92831
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + [histone] = CoA + acetyl- [histone]. {ECO:0000269|PubMed:8945521}.
DomainThe bromodomain mediates binding to HIV-1 Tat.
FunctionFunctions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:9707565}.
InteractionP03255:- (xeno); NbExp=3; IntAct=EBI-477430, EBI-2603114; P03255-2:- (xeno); NbExp=3; IntAct=EBI-477430, EBI-6859460; O60566:BUB1B; NbExp=13; IntAct=EBI-477430, EBI-1001438; Q92793:CREBBP; NbExp=4; IntAct=EBI-477430, EBI-81215; P03129:E7 (xeno); NbExp=5; IntAct=EBI-477430, EBI-866453; Q96KQ7:EHMT2; NbExp=3; IntAct=EBI-477430, EBI-744366; Q09472:EP300; NbExp=2; IntAct=EBI-477430, EBI-447295; Q16665:HIF1A; NbExp=2; IntAct=EBI-477430, EBI-447269; P02299:His3:CG33854 (xeno); NbExp=2; IntAct=EBI-477430, EBI-522090; P84040:His4:CG33909 (xeno); NbExp=2; IntAct=EBI-477430, EBI-185028; Q96EB6:SIRT1; NbExp=3; IntAct=EBI-477430, EBI-1802965; Q8IXJ6:SIRT2; NbExp=4; IntAct=EBI-477430, EBI-477232; Q16594:TAF9; NbExp=3; IntAct=EBI-477430, EBI-712521; O88898-2:Tp63 (xeno); NbExp=3; IntAct=EBI-477430, EBI-2338228; Q15672:TWIST1; NbExp=2; IntAct=EBI-477430, EBI-1797287; P22415:USF1; NbExp=5; IntAct=EBI-477430, EBI-1054489;
SimilarityBelongs to the acetyltransferase family. GCN5 subfamily. {ECO:0000305}.
SimilarityContains 1 bromo domain. {ECO:0000255|PROSITE- ProRule:PRU00035}.
SimilarityContains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule:PRU00532}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitInteracts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity (By similarity). Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. Interacts with NPAS2, ARNTL/BMAL1 and CLOCK. Interacts with BCAS3. {ECO:0000250, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:10766811, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:11931765, ECO:0000269|PubMed:12486002, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:15273251, ECO:0000269|PubMed:16887930, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9346901, ECO:0000269|PubMed:9707565}.
Tissue SpecificityUbiquitously expressed but most abundant in heart and skeletal muscle. {ECO:0000269|PubMed:8684459}.
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