MGP Database

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MGP003725

UniProt Annotations

Entry Information
Gene Namesynaptojanin 2
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=2B2; IsoId=O15056-1; Sequence=Displayed; Name=2B1; IsoId=O15056-2; Sequence=VSP_012911; Note=No experimental confirmation available.; Name=2A; IsoId=O15056-3; Sequence=VSP_012912, VSP_012913;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
FunctionInositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
InteractionP62993:GRB2; NbExp=2; IntAct=EBI-310513, EBI-401755; P16333:NCK1; NbExp=3; IntAct=EBI-310513, EBI-389883; Q96B97:SH3KBP1; NbExp=3; IntAct=EBI-310513, EBI-346595;
Sequence CautionSequence=AAH43277.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the synaptojanin family. {ECO:0000305}.
SimilarityContains 1 RRM (RNA recognition motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00176}.
SimilarityContains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
SimilarityIn the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}. Note=Predominantly associated with the particulate fractions. {ECO:0000250}.
SubunitBinds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.
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