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MGP003727

UniProt Annotations

Entry Information
Gene Namevanin 1
Protein EntryVNN1_HUMAN
UniProt IDO95497
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol.
FunctionAmidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269|PubMed:10567687, ECO:0000269|PubMed:11491533}.
InductionBy Th17/Th1 type cytokines, but not by Th2-type. {ECO:0000269|PubMed:19322213}.
SimilarityBelongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. {ECO:0000305}.
SimilarityContains 1 CN hydrolase domain. {ECO:0000255|PROSITE- ProRule:PRU00054}.
Subcellular LocationCell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Tissue SpecificityWidely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. {ECO:0000269|PubMed:19322213}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/vnn1/";
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