MGP Database

MGP003728

Ontology/Pathway Information

Entrez Gene ID8877
Gene Namesphingosine kinase 1
Gene Symbol SPHK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IEA:EnsemblCaxon
GO:0005737 IDA:HPACcytoplasm
GO:0005829 IEA:EnsemblCcytosol
GO:0005886 IDA:HPACplasma membrane
GO:0008021 IEA:EnsemblCsynaptic vesicle
GO:0004143 IEA:InterProFdiacylglycerol kinase activity
GO:0003951 IEA:InterProFNAD+ kinase activity
GO:0001568 IEA:EnsemblPblood vessel development
GO:0007420 IEA:EnsemblPbrain development
GO:0071363 IEA:EnsemblPcellular response to growth factor stimulus
GO:0070301 IEA:EnsemblPcellular response to hydrogen peroxide
GO:0009267 IEA:EnsemblPcellular response to starvation
GO:0019371 IEA:EnsemblPcyclooxygenase pathway
GO:0007565 IEA:EnsemblPfemale pregnancy
GO:0006954 IEA:EnsemblPinflammatory response
GO:0043066 IEA:EnsemblPnegative regulation of apoptotic process
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0010976 IEA:EnsemblPpositive regulation of neuron projection development
GO:0001956 IEA:EnsemblPpositive regulation of neurotransmitter secretion
GO:0001934 IEA:EnsemblPpositive regulation of protein phosphorylation
GO:0007205 IEA:InterProPprotein kinase C-activating G-protein coupled receptor signaling pathway
GO:0032651 IEA:EnsemblPregulation of interleukin-1 beta production
GO:0014075 IEA:EnsemblPresponse to amine
GO:0033198 IEA:EnsemblPresponse to ATP
GO:0070555 IEA:EnsemblPresponse to interleukin-1
GO:0032026 IEA:EnsemblPresponse to magnesium ion
GO:0032570 IEA:EnsemblPresponse to progesterone
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_16907Association of TriC/CCT with target proteins during biosynthesis
REACT_17004Chaperonin-mediated protein folding
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_17015Metabolism of proteins
REACT_16952Protein folding
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_115810Sphingolipid de novo biosynthesis
REACT_19323Sphingolipid metabolism
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
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