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MGP003740

UniProt Annotations

Entry Information

Gene Name	cyclin A1
Protein Entry	CCNA1_HUMAN
UniProt ID	P78396
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P78396-1; Sequence=Displayed; Name=2; IsoId=P78396-2; Sequence=VSP_034392; Name=3; IsoId=P78396-3; Sequence=VSP_044257;
Developmental Stage	Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.
Function	May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. {ECO:0000269\|PubMed:10022926}.
Interaction	P38936:CDKN1A; NbExp=3; IntAct=EBI-375065, EBI-375077;
Ptm	Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. {ECO:0000269\|PubMed:21596315}.
Similarity	Belongs to the cyclin family. Cyclin AB subfamily. {ECO:0000305}.
Subcellular Location	Nucleus {ECO:0000250}.
Subunit	Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9. {ECO:0000250, ECO:0000269\|PubMed:15159402}.
Tissue Specificity	Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CCNA1ID949ch13q13.html";