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MGP003741

Record overview

MGPD IDMGP003741
Gene ID8905
SpeciesHomo sapiens (Human)
Gene Nameadaptor-related protein complex 1, sigma 2 subunit
Gene Symbol AP1S2
SynonymsPGS; DC22; MRX59; MRXS5; MRXSF; MRXS21; SIGMA1B;
Alternate namesAP-1 complex subunit sigma-2; adapter-related protein complex 1 sigma-1B subunit; adaptor protein complex AP-1 sigma-1B subunit; adaptor-related protein complex 1 subunit sigma-1B; clathrin adaptor complex AP1 sigma 1B subunit; clathrin assembly protein complex 1 sigma-1B small chain; golgi adaptor HA1/AP1 adaptin sigma-1B subunit; sigma1B-adaptin;
ChromosomeX
Map LocationXp22.2
SummaryAdaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
OrthologsView orthologs and multiple alignments for AP1S2

Proteins

AP-1 complex subunit sigma-2 isoform 1
Refseq ID:NP_001259000
Protein GI:440918685
UniProt ID:F6SFB5
mRNA ID:NM_001272071
Length:160
RefSeq Status:
MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCEL
DIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEDAKEAETPRSVLEEIGLT
 
AP-1 complex subunit sigma-2 isoform 2
Refseq ID:NP_003907
Protein GI:22027655
UniProt ID:P56377
mRNA ID:NM_003916
Length:157
RefSeq Status:
MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCEL
DIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEEAETPRSVLEEIGLT
 
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