MGP Database

MGP003743

UniProt Annotations

Entry Information
Gene Nameglycogenin 2
Protein EntryGLYG2_HUMAN
UniProt IDO15488
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=Alpha; IsoId=O15488-1; Sequence=Displayed; Name=Beta; IsoId=O15488-2; Sequence=VSP_001770; Name=Gamma; IsoId=O15488-3; Sequence=VSP_001771; Name=Delta; IsoId=O15488-4; Sequence=VSP_001772; Name=Epsilon; IsoId=O15488-5; Sequence=VSP_001773; Name=Zeta; IsoId=O15488-6; Sequence=VSP_001774;
Catalytic ActivityUDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.;
FunctionSelf-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
Mass SpectrometryMass=55211.89; Method=MALDI; Range=1-501; Evidence={ECO:0000269|PubMed:11840567};
PathwayGlycan biosynthesis; glycogen biosynthesis.
PtmSelf-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228. {ECO:0000269|PubMed:9857012}.
SimilarityBelongs to the glycosyltransferase 8 family. Glycogenin subfamily. {ECO:0000305}.
SubunitHomodimer, tightly complexed to glycogen synthase.
Tissue SpecificityExpressed preferentially in liver, heart, and pancreas.
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