MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003752

Record overview

MGPD IDMGP003752
Gene ID8935
SpeciesHomo sapiens (Human)
Gene Namesrc kinase associated phosphoprotein 2
Gene Symbol SKAP2
SynonymsPRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM;
Alternate namessrc kinase-associated phosphoprotein 2; Fyn-associated phosphoprotein SKAP55 homologue; Pyk2/RAFTK-associated protein; SKAP-55HOM; SKAP55 homolog; retinoic acid-induced protein 70; src family-associated phosphoprotein 2; src kinase-associated phosphoprotein of 55-related protein; src-associated adapter protein with PH and SH3 domains;
Chromosome7
Map Location7p15.2
SummaryThe protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
OrthologsView orthologs and multiple alignments for SKAP2

Proteins

src kinase-associated phosphoprotein 2 isoform 1
Refseq ID:NP_003921
Protein GI:16753212
UniProt ID:O75563
mRNA ID:NM_003930
Length:359
RefSeq Status:
MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAP
SDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFT
AASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYAN
FYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI
 
src kinase-associated phosphoprotein 2 isoform 2
Refseq ID:NP_001290397
Protein GI:744066863
UniProt ID:
mRNA ID:NM_001303468
Length:187
RefSeq Status:
MNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSA
PVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI
 
  logo