MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003753

Record overview

MGPD IDMGP003753
Gene ID8936
SpeciesHomo sapiens (Human)
Gene NameWAS protein family, member 1
Gene Symbol WASF1
SynonymsWAVE; SCAR1; WAVE1;
Alternate nameswiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; homology of dictyostelium scar 1; protein WAVE-1; verprolin homology domain-containing protein 1;
Chromosome6
Map Location6q21
SummaryThe protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for WASF1

Proteins

wiskott-Aldrich syndrome protein family member 1
Refseq ID:NP_003922
Protein GI:4507913
UniProt ID:Q92558
mRNA ID:NM_003931
Length:559
RefSeq Status:
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKA
FRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDR
RREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA
TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPV
ARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIPASEPKRHPSTLPVISDARSV
LLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE
 
wiskott-Aldrich syndrome protein family member 1
Refseq ID:NP_001020107
Protein GI:68161504
UniProt ID:Q92558
mRNA ID:NM_001024936
Length:559
RefSeq Status:
Protein sequence is identical to GI:4507913 (mRNA isoform)
 
wiskott-Aldrich syndrome protein family member 1
Refseq ID:NP_001020106
Protein GI:68161502
UniProt ID:Q92558
mRNA ID:NM_001024935
Length:559
RefSeq Status:
Protein sequence is identical to GI:4507913 (mRNA isoform)
 
wiskott-Aldrich syndrome protein family member 1
Refseq ID:NP_001020105
Protein GI:68161500
UniProt ID:Q92558
mRNA ID:NM_001024934
Length:559
RefSeq Status:
Protein sequence is identical to GI:4507913 (mRNA isoform)
 
  logo